Endocrine Abstracts

A 44 year old woman presented in November 2000 with a two week history of headaches, vomiting and blurred vision. Past history consisted of type 2 diabetes and migraine. Initial investigation revealed hyponatraemia (sodium 114 mmol/l) and deranged liver biochemistry. ANA, anti dsDNA, cANCA, pANCA, anti Ro, La, RNP, Scl-70, Jo-1, smooth muscle and mitochondrial antibodies were negative. MRI revealed a 13x18x15mm pituitary mass elevating the optic chaism, without evidence of rec...

Advances in the treatment of acromegaly mean biochemical 'cure ' should be possible in the vast majority of patients. The challenge of the future will be designing treatment algorithms to optimise outcomes for individual patients, to ensure not only life expectancy but also QOL is normalised. QOL data is lacking in acromegaly, as is a disease-specific tool for measuring QOL. ACROQOL is a disease-specific QOL questionnaire compromising 22 questions (scored 1-5, high score good)...

Background: In asthmatic patients, in addition to conventional risk factors for osteoporosis, inflammatory factors and treatment with corticosteroids may also lead them to further bone loss. The trabecular bone score (TBS) is a new indirect parameter of bone quality. There has been no study which evaluates TBS in asthmatic patients according to use of corticosteroids.Objective: This study evaluated the TBS according to the severity of asthma and the corr...

Objective: Although the importance of islet α-cell dysfunction in the pathogenesis of type 2 diabetes has been reappraised, data on whether increase or decrease of glucagon relative to insulin is related with glucose metabolism parameters or metabolic diseases such as nonalcoholic fatty liver disease(NAFLD) in clinical settings are very limited. Therefore, we investigated the association between glucagon-to-insulin ratio(G/I ratio) and presence of NAFLD and metabolic para...

The advent of Web-based patient management technologies, including Web-based messaging, video conferencing, remote monitoring of vital signs, and Web-based educational programs, has resulted in the recognition that telemedicine may benefit diabetic patients with limited access to healthcare providers and/or a high burden of disease. In this regard, 24-week prospective multi-center randomized controlled trial involved 338 adult patients with type 2 diabetes at four university h...

Objectives: The aim of this study is to compare Friedewaldestimated and directly measured lowdensity lipoprotein cholesterol (LDLC) values and assess the concordance in guideline risk classification between the two methods.Methods: The data were derived from the 2009 to 2011 Korea National Health and Nutrition Survey (KNHANES). Analysis was done for 6454 subjects with lipid panels – total cholesterol (TC), directly measured LDL-C, high-density lipop...

Low-dose persistent organic pollutants (POPs), especially organochlorine pesticides (OCPs) and polychlorinated biphenyls (PCBs), have emerged as a new risk factor for type 2 diabetes. We evaluated whether chronic exposure to low-dose POPs affects insulin secretory function of β-cells in humans and in vitro cells. Serum concentrations of OCPs and PCBs were measured in 200 adults without diabetes. Mathematical model-based insulin secretion indices were estimated by...

Introduction: Hypoxia is involved with various physiological activities from glucose metabolism to tumor suppression. Hypoxia-inducible factor (HIF) is known as master regulator of oxygen homeostasis that triggers more than 1,000 related gene expressions. When hypoxia occurs, HIF1a protein is stabilized and starts transcription. Mucin1 mediates the stabilization of HIF1a in a cytoplasm. In addition, cytoplasmic domain of mucin1 and HIf1a form a transcriptional complex at glyco...

Evaluation of learning methods similar to deep learning and device using deep learning for the diagnosis of thyroid nodules.BackgroundWe recently developed a deep convolutional neural network algorithm (SEveRance Artificial intelligence program, SERA) using 13,560 ultrasonography images of thyroid nodules labeled benign and malignant and this algorithm showed comparable diagnostic performance with experienced radiologists. We wondered whether this self-learning method of SERA ...

Purpose: Although some studies presented good outcome of Radiofrequency Ablation (RFA) for Papillary Thyroid microcarcinoma (PTMC), its benefit has not been fully elucidated. The purpose of our study was to report the results from a prospective study investigating efficacy and safety of RFA in active surveillance candidate for low-risk PTMC. Materials and Methods: Since November 2018, RFA has been prospectively performed in active surveillance candidates...